Journal
AUTOPHAGY
Volume 1, Issue 3, Pages 131-140Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.1.3.2017
Keywords
antiaging interventions; caloric restriction; inummosenescence; insulin; lipofilscin; lysosomes; mitochondria turnover; protein turnover; replicative senescence
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Funding
- NIA NIH HHS [AG19834, AG021904] Funding Source: Medline
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A decrease in the turnover of cellular components and the intracellular accumulation of altered macromolecules and organelles are features common to all aged cells. Diminished autophagic activity plays a major role in these age-related manifestations. In this work we review the molecular defects responsible for the malfunctioning of two forms of autophagy, macroautophagy and chaperone-mediated outophagy, in old mammals, and highlight general and cell-type specific consequences of dysfunction of the autophagic system with age. Dietary caloric restriction and antilipolytic agents have been proven to efficiently stimulate autophagy in old rodents. These and other possible experimental restorative efforts are discussed.
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