Journal
MOLECULES
Volume 10, Issue 10, Pages 1318-1324Publisher
MDPI
DOI: 10.3390/10101318
Keywords
nitro reduction; cyclization; bicyclic 2-pyridones; imidazopyridines; thiazolopyridines
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Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are reported. These reactions afforded the target bicyclic 2-pyridones in good to excellent yields.
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