Journal
REPRODUCTIVE BIOMEDICINE ONLINE
Volume 11, Issue 4, Pages 476-485Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1472-6483(10)61144-3
Keywords
cardiomyocyte; differentiation; embryonic; human; stem; transplantation
Categories
Funding
- Medical Research Council [G113/30] Funding Source: researchfish
- MRC [G113/30] Funding Source: UKRI
- Medical Research Council [G113/30] Funding Source: Medline
Ask authors/readers for more resources
Cell transplantation is being discussed as a potential therapy for multiple disorders caused by loss or malfunction of single or at most a few cell types. These include diabetes, Parkinson's disease and myocardial infarction or cardiac failure. However, it is not yet clear whether cells from adult tissues ('adult stem cells') or embryos ('embryonic stem cells') will prove to be the most appropriate replacement cells; most likely, each disease will have its own preferred source. This study presents the background to this discussion and the current state of research in replacement of cardiac tissue, with focus on recent developments using human embryonic stem cells. It also describes a new human embryonic stem cell (HESC) line, NL-HESC1, the first to be derived in the Netherlands, and shows that it forms cardiac cells in a manner comparable with that of hES2 and hES3 cells grown in the same laboratory.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available