Journal
LIPIDS
Volume 40, Issue 10, Pages 1069-1073Publisher
WILEY
DOI: 10.1007/s11745-005-1471-4
Keywords
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Funding
- PHS HHS [048307] Funding Source: Medline
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Lutein is an oxygenated carotenoid (xanthophyll) found in dark green leafy vegetables. High intakes of lutein may lower the risk of age-related macular degeneration. Current understanding of human lutein metabolism as it might occur in vivo is incomplete. Therefore, we conducted a feasibility study where we dosed a normal adult woman with C-14-lutein (125 nmol, 36 nCi C-14), dissolved in olive oil (0.5 g/kg body weight) and mixed in a banana shake. Blood, urine, and feces collected before the dose was administered served to establish baseline values. Thereafter, blood was collected for 63 d following the dose, while feces and urine were collected for 2 wk post-dose. The 14C contents in plasma, urine, and feces were measured by accelerator MS. The C-14 first appeared in plasma 1 h after dosing and reached its highest level, approximate to 2.08% of dose/L plasma, at 14 h post-dose. The plasma pattern of 14 C did not include a chylomicrons/VLDL (intestinal) peak like that when the same subject received C-14-beta-carotene (a previous test), suggesting that lutein was handled differently from P-carotene by plasma lipoproteins. Lutein had an elimination half-life (t(1/2)) of approximate to 10 d. Forty-five percent of the dose of C-14 was eliminated in feces and 10% in urine in the first 2 d after dosing. Quantifying human lutein metabolism is a fertile area for future research.
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