4.6 Article

Do disparate mechanisms of duplication add similar genes to the genome?

Journal

TRENDS IN GENETICS
Volume 21, Issue 10, Pages 548-551

Publisher

ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2005.07.008

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Gene duplication is the fundamental source of new genes. Biases in duplication have profound implications for the dynamics of gene content during evolution. In this article, we compare genes arising from whole gene duplication (WGD), smaller scale duplication (SSD) and singletons in Saccharomyces cerevisiae. Our results demonstrate that genes duplicated by WGD and SSD are similarly biased with respect to codon bias and evolutionary rate, although differing significantly in their functional constituency.

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