Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 167, Issue 1-2, Pages 204-209Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.06.027
Keywords
TRAIL; flupirtine-maleate; neuroprotection; multiple sclerosis; apoptosis
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Neuronal damage mediated by the TRAIL-system might be involved in the pathogenesis of neuroinflammatory diseases of the central nervous system. Here we used an investigator-independent approach to quantify TRAIL-mediated death of total CNS cells and neurons in a living human brain slice culture system, a model which is much closer to the in vivo situation than dissociated cell culture. We observed dose-dependent TRAIL-mediated death of both total human CNS cells and neurons, which was prevented by flupirtine-maleate, a centrally acting analgesic drug with proposed neuroprotective properties. Our data suggest flupirtine-maleate as an orally available neuroprotective approach in the course of neuroinflammation. (C) 2005 Elsevier B.V. All rights reserved.
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