Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 17, Issue 5, Pages 463-467Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2005.07.002
Keywords
-
Categories
Ask authors/readers for more resources
Although it is clear that B cell genesis declines with age, the specifics of why this happens are largely unknown. Even less clear is how the age-related decline in B cell development might affect peripheral B cell function. Recent studies have investigated the impact of aging on both B cell genesis in the bone marrow and the resulting peripheral B cell repertoire. On the basis of these studies we propose a model in which the aging of very early B cell progenitors results in shifts in the peripheral B cell repertoire and, consequently, changes in mature B cell function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available