Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 33, Issue 4, Pages 195-200Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003677-200510000-00008
Keywords
arthritis; obesity; metabolic syndrome X; chondrocyte; exercise; biomechanics; adipokine
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Funding
- NIAMS NIH HHS [AR48182, AR50245, AR51672] Funding Source: Medline
- NIA NIH HHS [AG15768] Funding Source: Medline
- NIBIB NIH HHS [EB01630] Funding Source: Medline
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Osteoarthritis is a progressive joint disease characterized by an imbalance of articular cartilage biosynthesis and degradation attributed to both inflammatory and biomechanical factors. Whereas moderate mechanical loading appears necessary for maintaining healthy cartilage, abnormal joint loading increases the risk of osteoarthritis. Obesity-induced osteoarthritis and the benefits of physical activity may be mediated by systemic levels of proinflammatory mediators as well as local biomechanical factors in the joint.
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