Journal
JOURNAL OF CLINICAL PHARMACOLOGY
Volume 45, Issue 10, Pages 1145-1152Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0091270005279580
Keywords
micafungin; liver disease; renal disease; pharmacokinetics
Categories
Ask authors/readers for more resources
Micofungin is an antifungal agent metabolized by arylsulfatase with secondary metabolism by catechol-O-methyltransferose. The objectives of this study were to estimate the pharmacokinetic parameters and plasma protein binding of micafungin in volunteers with moderate hepatic dysfunction (n = 8), volunteers with creatinine clearance <30 mL/min (n = 9), and matched controls (n = 8 and n = 9, respectively). Single-dose micofungin pharmacokinetics were estimated using noncompartmental techniques. There was a statistically lower area under the observed micafungin concentration-time curve (AUC) from time 0 to infinity for subjects with moderate hepatic dysfunction as compared to control subjects (97.5 +/- 19 mu g center dot h/mL vs 125.9 +/- 26.4 mu g center dot h/mL, P = .03), although there was no difference in micafungin weight-adjusted clearance (10.9 +/- 1.7mL/h/kg vs 9.8 +/- 1.8 mL/h/kg, P = .2). The difference in area under the concentration-time curve may be explained by the differences in body weight between subjects and controls. Renal dysfunction did not alter micafungin pharmacokinetics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available