Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 17, Issue 5, Pages 476-479Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2005.07.003
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Funding
- NIA NIH HHS [P01 AG021600, R01 AG021054-03, R01 AG021054] Funding Source: Medline
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Immunological memory is one of the central features of the immune system and can be described as the ability of the immune system to respond more efficiently to a second encounter with the same pathogen. The immune system is dramatically affected by age-related changes and it is becoming apparent that immune memory exhibits significant defects as a result of aging. Although immune memory generated during youth functions well into old age, that generated later in life functions poorly. Importantly, age-related defects in the cognate helper function of CD4(+) T cells can potentially influence the development of both humoral and cell-mediated immune memory. These defects ultimately result in aged individuals who exhibit reduced responses to both infections and vaccinations.
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