Journal
PEPTIDES
Volume 26, Issue 10, Pages 1690-1696Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2004.11.027
Keywords
hyperactivity; food restriction; melanocortins; anorexia nervosa
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Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa (AN). In ABA, scheduled feeding in combination with voluntary access to running wheels, results in hyperactivity, hypophagia, body weight loss and activation of the HPA axis. Since stimulation of the melanocortin (MC) system has similar effects, this system is a candidate system involved in ABA. Here it is shown that chronic a-MSH treatment enhances ABA by increasing running wheel activity (RWA), decreasing food intake and increasing HPA axis activation. (c) 2005 Elsevier Inc. All rights reserved.
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