Journal
ANTIVIRAL RESEARCH
Volume 109, Issue -, Pages 97-109Publisher
ELSEVIER
DOI: 10.1016/j.antiviral.2014.06.013
Keywords
SARS-CoV; Other coronaviruses; Accessory proteins; Structure and function
Categories
Funding
- Competitive Research Programme (CRP) [R-154-000-529-281]
- National Research Foundation, Singapore
- Academic Research Fund (AcRF) Tier 1 grant [RGT17/13]
- Nanyang Technological University
- Ministry of Education, Singapore
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The huge RNA genome of SARS coronavirus comprises a number of open reading frames that code for a total of eight accessory proteins. Although none of these are essential for virus replication, some appear to have a role in virus pathogenesis. Notably, some SARS-CoV accessory proteins have been shown to modulate the interferon signaling pathways and the production of pro-inflammatory cytokines. The structural information on these proteins is also limited, with only two (p7a and p9b) having their structures determined by X-ray crystallography. This review makes an attempt to summarize the published knowledge on SARS-CoV accessory proteins, with an emphasis on their involvement in virus-host interaction. The accessory proteins of other coronaviruses are also briefly discussed. This paper forms part of a series of invited articles in Antiviral Research on From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses (see Introduction by Hilgenfeld and Peiris (2013)). (C) 2014 Elsevier B.V. All rights reserved.
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