Journal
ANTIVIRAL RESEARCH
Volume 100, Issue 1, Pages 246-254Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2013.08.014
Keywords
Coronavirus; Spike protein; Severe acute respiratory syndrome; Middle East respiratory syndrome; Virus evolution
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Funding
- NIH [R01AI089728]
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Receptor recognition is a major determinant of the host range, cross-species infections, and pathogenesis of the severe acute respiratory syndrome coronavirus (SARS-CoV). A defined receptor-binding domain (RBD) in the SARS-CoV spike protein specifically recognizes its host receptor, angiotensin-converting enzyme 2 (ACE2). This article reviews the latest knowledge about how RBDs from different SARS-CoV strains interact with ACE2 from several animal species. Detailed research on these RBD/ACE2 interactions has established important principles on host receptor adaptations, cross-species infections, and future evolution of SARS-CoV. These principles may apply to other emerging animal viruses, including the recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV). This paper forms part of a series of invited articles in Antiviral Research on From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. (C) 2013 Elsevier B.V. All rights reserved.
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