Journal
ANTIVIRAL RESEARCH
Volume 100, Issue 3, Pages 575-577Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2013.09.026
Keywords
Cytomegalovirus; Antiviral resistance; Ganciclovir; Foscarnet; Cidofovir
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Funding
- Else-Kroner-Fresenius Stiftung
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In transplant recipients, drug-resistant human cytomegalovirus (HCMV) infections remain a serious problem. Drug-resistance against ganciclovir (GCV), cidofovir (CDV) and foscarnet (PFA) is caused by mutations either in the phosphotransferase-gene (UL97) or in the viral polymerase (UL54). For characterization of newly emerging mutations marker transfer analysis is required. Two new HCMV-mutations, the UL54-mutation L516M and the UL97-mutation A613V, were characterized by this method. (C) 2013 Elsevier B.V. All rights reserved.
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