Journal
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
Volume 19, Issue 5, Pages 675-697Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bpg.2005.05.009
Keywords
duodenal carcinoid; carcinoid; gastrinoma; Zollinger-Ellison syndrome; somatostatinoma; MEN I; gangliocytic paraganglioma; von Recklinghausen's disease
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Duodenal neuroendocrine tumors (NETs) comprise 2-3% of all GI endocrine tumors and are increasing in frequency. These include gastrinomas, somatostatinomas, nonfunctional NETs, gangliocytic paragangliomas, and poorly differentiated NE carcinomas. Although, the majority are nonfunctional, these tumors are a frequent cause of Zollinger-Ellison syndrome and can cause other clinical hormonal syndromes (carcinoid, Cushing's, etc.). In this chapter, their epidemiology, clinical aspects, localization, diagnosis and medical treatment are reviewed including the latest advances in each area.
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