Journal
ENDOCRINE REVIEWS
Volume 26, Issue 6, Pages 743-774Publisher
ENDOCRINE SOC
DOI: 10.1210/er.2004-0001
Keywords
-
Categories
Ask authors/readers for more resources
TGF-beta 1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF-beta 1 plays a major role in development and maintenance, affecting both cartilage and bone metabolism, the latter being the subject of this review. Because it affects both cells of the osteoblast and osteoclast lineage, TGF-beta 1 is one of the most important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation. Many seemingly contradictory reports have been published on the exact functioning of TGF-beta 1 in the bone milieu. This review provides an overall picture of the bone-specific actions of TGF-beta 1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available