Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 94, Issue 4, Pages 2976-2982Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00235.2005
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- NINDS NIH HHS [NS-40413] Funding Source: Medline
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The physiological effects of ascending vagal afferent activity in the primate forebrain have not been established, and because vagus nerve stimulation ( VNS) is useful clinically for treatment of epilepsy and depression, these actions need to be identified. We used a roving microelectrode to record vagal- evoked potentials in the thalamus of the macaque monkey. In addition to the anticipated activation in the gustatory/ visceral thalamic relay nucleus, we found an unexpectedly larger and earlier response focus with multi- unit discharges in the adjacent parafascicular nucleus. These data reveal a potent vagal input to this intralaminar nucleus, which is normally considered to be involved in motor control. This finding indicates that a role for this vagal activation site in the anti- epileptic effects of VNS needs to be considered.
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