Journal
PHYTOTHERAPY RESEARCH
Volume 19, Issue 10, Pages 912-914Publisher
WILEY
DOI: 10.1002/ptr.1746
Keywords
doxorubicin; cardiotoxicity; tomato; lycopene
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The protective effect of tomato extract and lycopene on acute doxorubicin (DOX) myocardial toxicity was evaluated in mice. DOX toxicity, induced by a single intraperitoneal injection (15 mg/kg), was revealed by an elevated serum CPKMB and histopathological observations. Tomato extract (1.2 and 2.4 g/kg, i.p.) and lycopene (1.7 and 3.5 mg/kg, i.p.) prevented the rise in serum CPKMB and ameliorated cardiac cell injury. These results suggest that tomato extract and lycopene inhibit DOX cardiotoxicity and might serve as a novel combination chemotherapeutic agent with DOX to limit free radical-mediated organ injury. Copyright (c) 2005 John Wiley & Sons, Ltd.
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