Journal
ANTIVIRAL RESEARCH
Volume 92, Issue 1, Pages 15-26Publisher
ELSEVIER
DOI: 10.1016/j.antiviral.2011.07.013
Keywords
Monoclonal antibodies; Influenza viruses; Universal epitopes
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The role of humoral response in the effective control of infection by influenza viruses is well known, but the protection is usually limited to the infecting or vaccinating isolate and to few related strains. Recent studies have evidenced the existence of B-cell epitopes broadly conserved among different influenza subtypes recognized by monoclonal antibodies endowed with unprecedented broad activity. In this review, all major monoclonal antibodies directed against different influenza virus proteins are reported and their potential in the design of new anti-influenza prophylactic or therapeutic strategies is discussed. (C) 2011 Elsevier B.V. All rights reserved.
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