Journal
ANTIVIRAL RESEARCH
Volume 91, Issue 3, Pages 330-334Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2011.07.011
Keywords
Influenza; H5N1; Antiviral; Selective COX-2 inhibitor
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Funding
- Canadian Institutes of Health Research [TPA-90195]
- Research Fund for Control of Infectious Diseases [06060562]
- Research Grants Council [HKU 773707M]
- University Grants Committee, Hong Kong SAR Government [AoE/M-12/06]
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A selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease. (C) 2011 Elsevier B.V. All rights reserved.
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