Journal
ANTIVIRAL RESEARCH
Volume 89, Issue 1, Pages 124-126Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2010.11.013
Keywords
CpG oligodeoxynucleotide; H1N1 pandemic; Influenza A virus
Categories
Funding
- National 973 project of China [2010CB534002]
- National Science and Technology of China [2009ZX10004-401, 2009ZX10004-204]
Ask authors/readers for more resources
The 2009 H1N1 influenza virus pandemic poses a global public health threat, and there is a critical need for antiviral drugs for pandemic control. CpG oligodeoxynucleotides have strong immunostimulatory properties and are expected to be used as prophylactic agents to protect against microbial infections. The present study evaluated the efficacy of synthetic CpG oligodeoxynucleotide (ODN) 1826 against pandemic HIM virus infection in a murine model. A single injection of 15 mu g ODN 1826 intraperitoneally prior to virus challenge inhibits virus replication in lungs, reduces lung lesions and prevents mortality in mice, indicating CpG ODNs as a possible strategy for future influenza pandemics control. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available