Journal
TRENDS IN MICROBIOLOGY
Volume 13, Issue 10, Pages 459-462Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tim.2005.08.006
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Funding
- NIGMS NIH HHS [R01 GM57945] Funding Source: Medline
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Heterogeneous development of competence among cells of the bacterium Bacillus subtilis provides an appealing model of cell individuality, an area that is currently attracting considerable research interest. Under appropriate conditions, only a fraction of cells in an isogenic culture become competent for transformation. Two experimental studies have now pinpointed the same auto-stimulatory feedback loop of gene expression as the principal requirement for the establishment of this 'bistable' response.
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