Journal
IEEE TRANSACTIONS ON MAGNETICS
Volume 41, Issue 10, Pages 4102-4104Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMAG.2005.855338
Keywords
in vivo; magnetic resonance imaging (MRI) contrast agent; nano-size; sonochemistry; ultrasuperpara magnetic iron oxide (USPIO)-chitosan
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Ultrasuperpara magnetic iron oxide (USPIO) nanoparticles were synthesized with iron chloride using a sonochemical method. The size of the USPIO nanoparticles was controlled by ultrasonic exposure time and power. The USPIO nanoparticles had a narrow size distribution, a perfect magnetite crystal structure, and high saturation magnetization. The magnetic resonance imaging (MRI) contrast agent was prepared by coating the USPIO and dispersing it with biocompatible chitosan. In vivo testing in New Zealand white rabbits confirmed the effectiveness of the USPIO nanoparticles as a MRI contrast agent.
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