Journal
TRENDS IN IMMUNOLOGY
Volume 26, Issue 10, Pages 509-511Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2005.08.006
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Funding
- NIAID NIH HHS [R21 AI 060737] Funding Source: Medline
- NIGMS NIH HHS [R01 GM 54060] Funding Source: Medline
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Toll-like receptors (TLRs) are primordial pathogen-recognition proteins that function as sentinels for the innate immune system. One of the TLR mysteries relates to TLR11, a receptor present in mice, but not humans, and known to recognize uropathogenic Escherichia coli. The first defined ligand for TLR11 has now been described as a profilin-like protein from Toxoplasma gondii. This discovery potentially gives us important clues as to how a gene expressed in mice, but not humans, actually relates to human infectious diseases.
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