Journal
ANTIVIRAL RESEARCH
Volume 84, Issue 2, Pages 119-130Publisher
ELSEVIER
DOI: 10.1016/j.antiviral.2009.08.008
Keywords
Immunological memory; T cell; B cell; Antibody; Vaccine; Virus
Categories
Funding
- NIH [R43 A1079898, R56 A1076506, U54 A1081680, U01 A1082196]
- Oregon National Primate Research Center [RR0001 63]
Ask authors/readers for more resources
Vaccination is one of the most effective methods used for protecting the public against infectious disease. Vaccines can be segregated into two general categories: replicating vaccines (i.e., live, attenuated vaccines) and non-replicating vaccines (e.g., inactivated or subunit vaccines). It has been assumed that live attenuated vaccines are superior to non-replicating vaccines in terms of the quality of the antiviral immune response, the level of protective immunity, and the duration of protective immunity. Although this a prevalent viewpoint within the field, there are several exceptions to the rule. Here, we will explore the historical literature in which some of these conclusions have been based, including Experiments of Nature and describe examples of the efficacy of replicating vaccines compared to their non-replicating counterparts. By building a better understanding of how successful vaccines work, we hope to develop better next-generation vaccines as well as new vaccines against HIV-a pathogen of global importance for which no licensed vaccine currently exists. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available