Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 115, Issue 10, Pages 2648-2655Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI26250
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Funding
- NCI NIH HHS [K08 CA10254] Funding Source: Medline
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The commitment to programmed cell death involves complex interactions among pro- and antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision by these proteins to undergo cell death is permeabilization of the mitochondrial outer membrane. Pharmacologic manipulation of proteins in this family appears both feasible and efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or brain, or increased cell death, as in cancer.
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