Journal
FEMS MICROBIOLOGY LETTERS
Volume 251, Issue 1, Pages 53-58Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2005.07.025
Keywords
marine; lignicolous fungi; Diaporthe sp.; metabolites; cytotoxic; antimicrobial
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A new compound (1), named diaporthelactone, together with two known compounds (2 and 3) were isolated from the culture of Diaporthe sp., a marine fungus growing in the submerged rotten leaves of Kandelia candel in the mangrove nature conservation areas of Fugong, Fujian Province of China. The new compound was elucidated to be 1,3-dihydro-4-methoxy-7methyl-3-oxo-5-isobenzofuran-carboxyaldehyde (1), which showed cytotoxic activity against KB and Raji cell lines (IC50 6.25 and 5.51 mu G mL(-1), respectively). Two known compounds, 7-methoxy-4,6-dimethyl-3H-isobenzofuran-1-one (2) and mycoepoxydiene (3), were also demonstrated to exhibit cytotoxic activities for the first time. All three compounds were assessed for antimicrobial activity. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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