Journal
BIOPHYSICAL JOURNAL
Volume 89, Issue 4, Pages 2395-2401Publisher
CELL PRESS
DOI: 10.1529/biophysj.105.065904
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Funding
- NIGMS NIH HHS [R01-GM067801, R01 GM067801] Funding Source: Medline
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We examined the role of molecular shape in determining the patterns of low-frequency deformational motions of biological macromolecules. The low-frequency subspace of eigenvectors in normal mode analysis was found to be robustly similar upon randomization of the Hessian matrix elements as long as the structure of the matrix is maintained, which indicates that the global shape of molecules plays a more dominant role in determining the highly anisotropic low-frequency motions than the absolute values of stiffness and directionality of local interactions. The results provided a quantitative foundation for the validity of elastic normal mode analysis.
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