Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 126, Issue 10, Pages 1130-1133Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2005.05.004
Keywords
replicative senescence; aging; longevity; body mass; fibroblast
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Funding
- NIA NIH HHS [AG20955, AG022873] Funding Source: Medline
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Although the limited replicative capacity of human fibroblasts in culture is frequently used as a model for aging, a question of major interest is whether the relationship between in vitro fibroblast proliferative capacity and species longevity is primary or secondary to a relationship with species body size. In this report we establish that body mass is the primary correlative of proliferative potential rather than species life-span. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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