Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 53, Issue 10, Pages 1359-1361Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.53.1359
Keywords
dihydropyrazine; DNA strand-breakage; 1,2-diamine; alpha-diketone; cyclocondensation
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Treatment of 1,2-cyclohexanedione with 1,2-diamines, e.g. ethylenediamine and cis-(and trans-)1,2-diaminocyclohexane, caused [4+2] cyclocondensation to give the corresponding dihydropyrazine derivatives (compounds 1-6). They exhibited stronger DNA strand-breakage activity than that of dihydropyrazines, which has already been reported in previous papers.
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