Journal
TISSUE ANTIGENS
Volume 66, Issue 4, Pages 314-317Publisher
WILEY
DOI: 10.1111/j.1399-0039.2005.00428.x
Keywords
Crohn's disease; PTPN22; inflammatory bowel disease; lymphoid-specific phosphatase (LYP); ulcerative colitis
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The aim of this study was to assess the possible association between the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene 1858C -> T (rs2476601, encoding R620W) polymorphism and inflammatory bowel disease (IBD). Our study population consisted of 1113 IBD [544 ulcerative colitis (UC) and 569 Crohn's disease (CD)] patients and 812 healthy subjects. All the individuals were of Spanish white origin. Genotyping of the PTPN22 gene 1858C -> T polymorphism was performed by real time polymerase chain reaction technology, using TaqMan 5'-allelic discrimination assay. The frequency of the PTPN22 1858T allele in healthy subjects was 6.2% compared with 6.7% in the UC patients and 5.1% in Crohn's patients. No statistically significant differences were observed when the PTPN22 1858C -> T allele and genotype distribution among CD patients, UC patients and healthy controls were compared. These results indicate that the PTPN22 1858C -> T polymorphism does not appear to play a major role in IBD predisposition in our population.
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