Journal
ZEITSCHRIFT FUR GASTROENTEROLOGIE
Volume 43, Issue 10, Pages 1133-1139Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-858638
Keywords
Akt; protein kinase B; PI-3 kinase; gastrointestinal; tumor; signaling; survival; proliferation; apoptosis; metastasis
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The lipid kinase phosphoinositide 3-OH kinase (PI3K) and its downstream target Akt, also known as protein kinase B (PKB), are crucial effectors in oncogenic signaling induced by various receptor-tyrosine kinases. In recent years, data are accumulating that PI3K/Akt signaling components are frequently altered in a variety of human malignancies. This review summarizes the major effects of PI3K/Akt signaling on proliferation, survival and resistance to apoptosis, angiogenesis and cell motility in gastrointestinal cancers. In addition, activation of PI3K/Akt by various growth factors, the modulation of downstream targets by Akt-induced phosphorylation as well as novel treatment strategies targeting this pathway in gastrointestinal tumors are discussed.
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