Journal
MOLECULES
Volume 10, Issue 10, Pages 1298-1306Publisher
MDPI
DOI: 10.3390/10101298
Keywords
pyrazolo[4,3-e][1,2,4]triazines; purine analogues; enzyme inhibitors
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Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with K-i values in the 10(-3) 10(-5) M range.
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