Journal
TRENDS IN IMMUNOLOGY
Volume 26, Issue 10, Pages 535-542Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2005.08.002
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Insulin-like growth factor-I (IGF-1) is an important mediator in numerous developmental processes, such as proliferation, differentiation, survival, growth, apoptosis and regeneration. Mouse genetics have provided important insights into the signalling mechanisms that are necessary for the coordination of muscle repair. Recent studies on the role of IGF-1 in the promotion of cell recruitment to the injured muscle and the subsequent resolution of the inflammatory response have unveiled new perspectives into local repair mechanisms.
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