Journal
EXPERIMENTAL NEUROLOGY
Volume 195, Issue 2, Pages 400-406Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2005.06.005
Keywords
neonatal hypoxia-ischemia; glutamate uptake; guanosine; hippocampal slices
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Brain injury secondary to hypoxic-ischemic disease is the predominant form of damage encountered in the perinatal period. The impact of neonatal hypoxia-ischemia (HI) in 7-day-old pups on the high-affinity [H-3] glutamate uptake into hippocampal slices at different times after insult was examined. Immediately following, and 1 day after the insult there was no effect. But at 3 to 5 days after the HI insult, glutamate uptake into the hippocampus was markedly reduced; however, after 30 or 60 days the glutamate uptake into hippocampal slices returned to control levels. Also, this study demonstrated the effect of the nucleoside guanosine (Guo) on the [H-3] glutamate uptake in neonatal HI injury, maintaining the [H-3] glutamate uptake at control levels when injected before and after insult HI. We conclude that neonatal HI influences glutamate uptake a few days following insult, and that guanosine prevents this action. (c) 2005 Elsevier Inc. All rights reserved.
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