Redox Pioneer: Professor Joe M. McCord

Dr. Joe McCord (Ph.D. 1970) is recognized here as a Redox Pioneer because he has published at least three articles on antioxidant/redox biology as first/last author that have been cited over 1000 times and has published at least 37 articles each cited over 100 times. Dr. McCord is known for the monumental discovery of the antioxidant superoxide dismutase (SOD) while a graduate student under fellow redox pioneer Irwin Fridovich and demonstrating its necessity to aerobic life. Beyond this, McCord's career is distinguished for bridging the gap from basic science to clinical relevance by showing the application of SOD and superoxide to human physiology, and characterizing the physiological functions of superoxide in inflammation, immunological chemotaxis, and ischemia-reperfusion injury, among other disease conditions. Work by McCord serves as the foundation upon which our understanding of how superoxide functions in a variety of physiological systems is built and demonstrates how superoxide is essential to aerobic life, yet, if left unchecked by SOD, toxic to a multitude of systems. These discoveries have substantial significance in a wide range of studies with applications in cardiovascular disease, cancer, neurology, and medicine, as well as general health and longevity. Dr. McCord's contributions to free radical biology have been recognized through many prestigious achievement awards, honorary titles, and conferences around the world; each serving as a testament to his status as a redox pioneer. Antioxid. Redox Signal. 20, 183-188.