Journal
SEMINARS IN CANCER BIOLOGY
Volume 15, Issue 5, Pages 342-352Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2005.05.001
Keywords
basement membrane; mammary gland; microenvironment; morphogenesis; therapy; tissue structure
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Funding
- NCI NIH HHS [R01 CA064786, R01 CA057621-07, CA57621, CA64786, R01 CA057621, R01 CA064786-05, R37 CA064786] Funding Source: Medline
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In order to understand why cancer develops as well as predict the outcome of pharmacological treatments, we need to model the structure and function of organs in culture so that our experimental manipulations occur under physiological contexts. This review traces the history of the development of a prototypic example, the three-dimensional (3D) model of the mammary gland acinus. We briefly describe the considerable information available on both normal mammary gland function and breast cancer generated by the current model and present future challenges that will require an increase in its complexity. We propose the need for engineered tissues that faithfully recapitulate their native structures to allow a greater understanding of tissue function, dysfunction, and potential therapeutic intervention. (c) 2005 Elsevier Ltd. All rights reserved.
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