Journal
TRENDS IN CELL BIOLOGY
Volume 15, Issue 10, Pages 514-517Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2005.08.003
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Ezh2, a polycomb group protein, is known to function in histone methylation, thereby regulating gene expression. However, in a recent study by Su et al., the Ezh2-containing complex has been given an additional role in cellular regulation. Cytosolic Ezh2 methyltransferase complexes were shown to associate with Vav1 and control receptor-induced actin polymerization and proliferation in a methylation-dependent manner. Overall, these findings implicate lysine methylation as a posttranslational modification crucial for receptor-mediated signal transduction events.
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