4.7 Review

Parenteral Ascorbate As a Cancer Therapeutic: A Reassessment Based on Pharmacokinetics

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

Vitamin C in mouse and human red blood cells: An HPLC assay

Hongyan Li et al.

ANALYTICAL BIOCHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

Lin Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Biochemistry & Molecular Biology

Enhanced antitumor activity of vitamin C via p53 in Cancer cells

Jinsun Kim et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Review Medicine, General & Internal

Iron Overload in Human Disease

Robert E. Fleming et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Biochemistry & Molecular Biology

Selective Ascorbate Toxicity in Malignant Mesothelioma A Redox Trojan Mechanism

Elia Ranzato et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer

Michael Graham Espey et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Biology

Ascorbic Acid Enhances Radiation-induced Apoptosis in an HL60 Human Leukemia Cell Line

Koji Shinozaki et al.

JOURNAL OF RADIATION RESEARCH (2011)

Article Multidisciplinary Sciences

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol

David A. Andersson et al.

NATURE COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

High dose of ascorbic acid induces cell death in mesothelioma cells

Yukitoshi Takemura et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Oncology

Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer

Juan Du et al.

CLINICAL CANCER RESEARCH (2010)

Article Medicine, Research & Experimental

Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice

Christopher P. Corpe et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Multidisciplinary Sciences

Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects

Sebastian J. Padayatty et al.

PLOS ONE (2010)

Letter Oncology

Comment re: Vitamin C Antagonizes the Cytotoxic Effects of Chemotherapy

Michael Graham Espey et al.

CANCER RESEARCH (2009)

Article Biochemistry & Molecular Biology

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

Julien Verrax et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Article Biochemistry & Molecular Biology

Proteomic Analysis Reveals Upregulation of RKIP in S-180 Implanted BALB/C Mouse After Treatment With Ascorbic Acid

Seyeon Park et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2009)

Article Oncology

Phase I clinical trial of i.v. ascorbic acid in advanced malignancy

L. J. Hoffer et al.

ANNALS OF ONCOLOGY (2008)

Article Oncology

Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs

Mark L. Heaney et al.

CANCER RESEARCH (2008)

Article Medicine, Research & Experimental

Anti-angiogenic effect of high doses of ascorbic acid

Nina A. Mikirova et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2008)

Article Multidisciplinary Sciences

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

Qi Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma

Eunsil Hahm et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Sodium ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake

Roberta Carosio et al.

MOLECULAR CANCER (2007)

Article Multidisciplinary Sciences

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

Qi Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Medicine, General & Internal

Changes of terminal cancer patients' health-related quality of life after high dose vitamin C administration

Chang Hwan Yeom et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2007)

Article Medicine, General & Internal

Intravenously administered vitamin C as cancer therapy: three cases

SJ Padayatty et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2006)

Review Biotechnology & Applied Microbiology

Model organisms - The mighty mouse: genetically engineered mouse models in cancer drug development

Norman E. Sharpless et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Oncology

Vitamin C enhances chemosensitization of esophageal cancer cells in vitro

MMM Abdel-Latif et al.

JOURNAL OF CHEMOTHERAPY (2005)

Article Multidisciplinary Sciences

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

Q Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Oncology

Phase I trial of menadiol diphosphate (vitamin K3) in advanced malignancy

D Lim et al.

INVESTIGATIONAL NEW DRUGS (2005)

Article Medicine, General & Internal

Vitamin C pharmacokinetics: Implications for oral and intravenous use

SJ Padayatty et al.

ANNALS OF INTERNAL MEDICINE (2004)

Article Biochemistry & Molecular Biology

L-ascorbic acid represses constitutive activation of NF-κB and COX-2 expression in human acute myeloid leukemia, HL-60

SS Han et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2004)

Article Multidisciplinary Sciences

A new recommended dietary allowance of vitamin C for healthy young women

M Levine et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Pharmacology & Pharmacy

The Haber-Weiss reaction and mechanisms of toxicity

JP Kehrer

TOXICOLOGY (2000)