Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 17, Issue 1, Pages 32-44Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2011.4401
Keywords
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Funding
- National Science Foundation [IBN 0235223, IOS 0641436, IOS 1051627]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1051627] Funding Source: National Science Foundation
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Significance: Hydrogen sulfide (H2S) is garnering increasing interest as a biologically relevant signaling molecule. The effects of H2S have now been observed in virtually every organ system and numerous physiological processes. Recent Advances: These studies have not only opened a new field of gasotransmitter biology, they have also led to the development of synthetic H2S donating compounds with the potential to be parlayed into a variety of therapeutic applications. Critical Issues: Often lost in the exuberance of this new field is a critical examination or understanding of practical aspects of H2S chemistry and biology. This is especially notable in the areas of handling and measuring H2S, evaluating biosynthetic and metabolic pathways, and separating physiological from pharmacological responses. Future Directions: This brief review describes some of the pitfalls in H2S chemistry and biology that can lead or have already led to misleading or erroneous conclusions. The intent is to allow individuals entering or already in this burgeoning field to critically analyze the literature and to assist them in the design of future experiments. Antioxid. Redox Signal. 17, 32-44.
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