Dendritic cells, DRiPs, and DALIS in the control of antigen processing

The study of the cell biology of antigen processing and presentation has greatly contributed to our understanding of the immune response. The work of many immunologically inclined cell biologists has also permitted new insights into cellular mechanisms shared by many cell types. Here are described recent and particularly exciting findings on the regulation of major histocompatibility complex class I-restricted presentation in dendritic cells and their contribution to the deciphering of the cellular response to pathogen detection.