Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 62, Issue 19-20, Pages 2161-2172Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5160-x
Keywords
mechanisms of peptidase action; beta-lactamase; cytomegalovirus; Ntp-hydrolyses; oxyanion binding site
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Funding
- Wellcome Trust Funding Source: Medline
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The catalytic action of serine peptidases depends on the interplay of a nucleophile, a general base and an acid. In the classic trypsin and subtilisin families this catalytic triad is composed of serine, histidine and aspartic acid residues and exhibits similar spatial arrangements, but the order of the residues in the amino acid sequence is different. By now several new families have been discovered, in which the nucleophile-base-acid pattern is generally conserved, but the individual components can vary. The variations illustrate how different groups and different protein structures achieve the same reaction.
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