Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 15, Issue 4, Pages 911-914Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2010.3803
Keywords
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Funding
- NHLBI NIH HHS [R01 HL077524, HL077524-S1] Funding Source: Medline
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Endothelial progenitor cells (EPCs) represent a heterogeneous population of cells with a pro-angiogenic potential that are derived not only from bone marrow but also from other tissues. Depending on the model and cell type used, the pro-angiogenic effect is a consequence of direct vascular integration, the paracrine release of growth factors and cytokines, or complex interactions with other cellular components like monocytes or platelets. The pro-angiogenic potential of EPCs is dependent on the particular type of EPC studied and modulated by the risk and life style factors of the patient as well as by local factors determining the homing to diseased tissue and the EPC proteome. In this Forum on EPCs these aspects will be covered in individual review articles, which are accompanied by two original research studies on the role of NADPH oxidases for EPC mobilization and the impact of organic nitrates on EPCs. Antioxid. Redox Signal. 15, 911-914.
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