Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 15, Issue 9, Pages 2487-2499Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2011.3909
Keywords
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Funding
- Australian National Health and Medical Research Council
- Australian Research Council
- Swedish Research Council
- Swedish National Center for Sports Research
- Association Francaise contre les Myopathies (AFM)
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Reactive oxygen and nitrogen species (ROS/RNS) are involved in numerous aspects of cellular signaling. Classically ROS/RNS have been associated with cellular dysfunction and disease, but it is now clear that they are also of integral importance under normal conditions. In this review, we discuss ROS/RNS effects in skeletal muscle, with special focus on changes in contractile function. The review deals with the tentative roles of ROS/RNS for acute changes that can occur during strenuous exercise resulting in muscle fatigue, for the recovery from fatigue, and for the effects of training/overtraining. We also discuss two groups of inherited diseases; muscle dystrophies, where recent data suggest that ROS/RNS may be of unexpectedly large importance, and mitochondrial myopathies, where the role of ROS seems more limited than originally thought. Antioxid. Redox Signal. 15, 2487-2499.
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