Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 14, Issue 2, Pages 261-273Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2010.3241
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Funding
- NIH [5P51 RR00163-47, 5P51 RR00163-48, T32 AI007472-12]
- American Federation for Aging Research [A07136]
- I. Messaoudi [CA132638-01]
- NATIONAL CANCER INSTITUTE [R01CA132638, R01CA075922] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P51RR000163] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007472] Funding Source: NIH RePORTER
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Nonhuman primates have been used for biomedical research for several decades. The high level of genetic homology to humans coupled with their outbred nature has made nonhuman primates invaluable preclinical models. In this review, we summarize recent advances in our understanding of the nonhuman primate immune system, with special emphasis on studies carried out in rhesus macaque (Macaca mulatta). We highlight the utility of nonhuman primates in the characterization of immune senescence and the evaluation of new interventions to slow down the aging of the immune system. Antioxid. Redox Signal. 14, 261-273.
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