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Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2α deacetylase activity
JB Pillai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress
L Tretter et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2005)
Diesel exhaust activates redox-sensitive transcription factors and kinases in human airways
J Pourazar et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)
Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate
LA McNeill et al.
MOLECULAR BIOSYSTEMS (2005)
Histone H3 modifications in rat hepatic stellate cells by ethanol
JS Kim et al.
ALCOHOL AND ALCOHOLISM (2005)
Mitochondrial energy metabolism is markedly impaired by D-2-hydroxyglutaric acid in rat tissues
A Latini et al.
MOLECULAR GENETICS AND METABOLISM (2005)
Calorie restriction and SIR2 genes - Towards a mechanism
L Guarente
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway
A Rivera et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells
YM Liu et al.
CARCINOGENESIS (2005)
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
JS Isaacs et al.
CANCER CELL (2005)
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
JJ Kovacs et al.
MOLECULAR CELL (2005)
Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1α accumulation-implications for prolyl hydroxylase activity and iron
M Callapina et al.
EXPERIMENTAL CELL RESEARCH (2005)
Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
P Bubber et al.
ANNALS OF NEUROLOGY (2005)
Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process
F Forneris et al.
FEBS LETTERS (2005)
Methylation: lost in hydroxylation?
SC Trewick et al.
EMBO REPORTS (2005)
Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
M Gatz et al.
NEUROBIOLOGY OF AGING (2005)
Iron regulatory protein 1 as a sensor of reactive oxygen species
S Mueller
BIOFACTORS (2005)
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
MA Selak et al.
CANCER CELL (2005)
The SET-domain protein superfamily: protein lysine methyltransferases
SC Dillon et al.
GENOME BIOLOGY (2005)
Epigenetic silencing of DSC3 is a common event in human breast cancer
MM Oshiro et al.
BREAST CANCER RESEARCH (2005)
Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis
IV Gregoretti et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Poly(ADP-ribosyl)ated chromatin domains: access granted
M Rouleau et al.
JOURNAL OF CELL SCIENCE (2004)
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration
K Ito et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Histone deimination antagonizes arginine methylation
GL Cuthbert et al.
CELL (2004)
Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-κB activation and proinflammatory cytokine release in alveolar epithelial cells
FM Moodie et al.
FASEB JOURNAL (2004)
Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
YJ Shi et al.
CELL (2004)
Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases
JR Somoza et al.
STRUCTURE (2004)
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes
R Schneider et al.
NATURE CELL BIOLOGY (2004)
HIF-1 - An oxygen and metal responsive transcription factor
P Maxwell et al.
CANCER BIOLOGY & THERAPY (2004)
A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria
R Rzem et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Aberrant methylation of the maspin promoter is an early event in human breast cancer
BW Futscher et al.
NEOPLASIA (2004)
Human PAD4 regulates histone arginine methylation levels via demethylimination
Y Wang et al.
SCIENCE (2004)
L-2-hydroxyglutaric aciduria and brain malignant tumors - A predisposing condition?
I Moroni et al.
NEUROLOGY (2004)
Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome
GN Liang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
Y Kawaguchi et al.
CELL (2003)
Acetaminophen-induced hepatotoxicity
LP James et al.
DRUG METABOLISM AND DISPOSITION (2003)
Labile iron pool: the main determinant of cellular response to oxidative stress
M Kruszewski
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
Induction of oxidative stress by L-2-hydroxyglutaric acid in rat brain
A Latini et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
M Hirsilä et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Increased, homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease
R Castro et al.
CLINICAL CHEMISTRY (2003)
Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked?
J Zhang
BIOESSAYS (2003)
Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure
Y Yan et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)
Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases
E Metzen et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Mitochondrial complex I, aconitase, and succinate dehydrogenase during hypoxia-reoxygenation: modulation of enzyme activities by MnSOD
CS Powell et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2003)
Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression
N Fujita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes
PH Park et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
A role for poly(ADP-ribosyl)ation in DNA methylation
G Zardo et al.
BIOCHEMISTRY AND CELL BIOLOGY (2003)
A novel jmjC domain protein modulates heterochromatization in fission yeast
N Ayoub et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats
A Latini et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
F Fuks et al.
NUCLEIC ACIDS RESEARCH (2003)
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
SJ Lin et al.
CURRENT OPINION IN CELL BIOLOGY (2003)
2-oxo acid dehydrogenase complexes in redox regulation - Role of the lipoate residues and thioredoxin
VI Bunik
EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)
Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci
A Tulin et al.
SCIENCE (2003)
Methylation of histone H3K4 mediates association of the Isw1p ATPase with chromatin
H Santos-Rosa et al.
MOLECULAR CELL (2003)
Reversal of DNA alkylation damage by two human dioxygenases
T Duncan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1
KJ Bitterman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine
PD Mongan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)
Cytopathies involving mitochondrial complex II
Brian A. C. Ackrell
MOLECULAR ASPECTS OF MEDICINE (2002)
Active genes are tri-methylated at K4 of histone H3
H Santos-Rosa et al.
NATURE (2002)
AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
PO Falnes et al.
NATURE (2002)
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
SC Trewick et al.
NATURE (2002)
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
KS Hewitson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
SJ Lin et al.
NATURE (2002)
Medulloblastoma in a child with the metabolic disease L-2-Hydroxyglutaric aciduria
PA Özisik et al.
PEDIATRIC NEUROSURGERY (2002)
S-Adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease
JC Fernández-Checa et al.
ALCOHOL (2002)
Inhibition of poly(ADP-ribosyl)ation induces DNA hypermethylation: a possible molecular mechanism
G Zardo et al.
FASEB JOURNAL (2002)
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels
RM Anderson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
HDAC6 is a microtubule-associated deacetylase
C Hubbert et al.
NATURE (2002)
Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centred rearrangements
ZH Zhang et al.
FEBS LETTERS (2002)
Methionine synthase: a possible prime site of the ethanolic lesion in liver
AJ Barak et al.
ALCOHOL (2002)
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
AHFM Peters et al.
NATURE GENETICS (2002)
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway
AP Gimenez-Roqueplo et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Oxidative damage is the earliest event in Alzheimer disease
A Nunomura et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2001)
Mitochondrial abnormalities in Alzheimer's disease
K Hirai et al.
JOURNAL OF NEUROSCIENCE (2001)
Functional mitochondria are required for amyloid β-mediated neurotoxicity
SM Cardoso et al.
FASEB JOURNAL (2001)
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
J Nakayam et al.
SCIENCE (2001)
Histone acetyltransferases: function, structure, and catalysis
R Marmorstein et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2001)
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
M Lachner et al.
NATURE (2001)
Initial sequencing and analysis of the human genome
ES Lander et al.
NATURE (2001)
PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2, 6-bisphosphate
DO Okar et al.
TRENDS IN BIOCHEMICAL SCIENCES (2001)
Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
KG Tanner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma
MA Avila et al.
JOURNAL OF HEPATOLOGY (2000)
Role of NAD+ in the deacetylase activity of the SIR2-like proteins
J Landry et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Neuronal oxidative stress precedes amyloid-β deposition in Down syndrome
A Nunomura et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2000)
The DNA methyltransferases of mammals
TH Bestor
HUMAN MOLECULAR GENETICS (2000)
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
SJ Lin et al.
SCIENCE (2000)
Overexpression of wild type and mutated human ferritin H-chain in HeLa cells -: In vivo role of ferritin ferroxidase activity
A Cozzi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
NuRD and SIN3 - histone deacetylase complexes in development
J Ahringer
TRENDS IN GENETICS (2000)
Base excision repair is impaired in mammalian cells lacking poly(ADP-ribose) polymerase-1
F Dantzer et al.
BIOCHEMISTRY (2000)
The histone deacetylase-3 complex contains nuclear receptor corepressors
YD Wen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
CPG methylation as a mechanism for the regulation of E2F activity
MR Campanero et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
JS Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
The silencing protein SIR2 and its homologs are MAD-dependent protein deacetylases
J Landry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
S Imai et al.
NATURE (2000)