Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 14, Issue 8, Pages 1493-1504Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2010.3580
Keywords
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Funding
- Silvo O. Conte Center [MH-084018, MH-069853, MH-088753]
- Stanley
- CHDI
- HighQ
- NARSAD
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Nitric oxide (NO) mediates cellular signaling pathways that regulate a plethora of physiological processes. One of the signaling mechanisms mediated by NO is through S-nitrosylation of cysteine residues in target proteins, which is now regarded as an important redox-based physiological action. Deregulation of the protein S-nitrosylation upon nitrosative stress, however, has also been linked to various human diseases, such as neurodegenerative disorders. Between these physiological and pathophysiological roles, there are mechanisms whereby a milder level of nitrosative stress provides S-nitrosylation of some proteins that counteracts the pathological processes, serving as a negative feedback mechanism. In addition, NO has recently emerged as a mediator of epigenetic gene expression and chromatin changes. In this review, these molecular mechanisms, especially those in the central nervous system and neurodegenerative disorders, are described. Antioxid. Redox Signal. 14, 1493-1504.
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