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LA Videla et al.
CLINICAL SCIENCE (2004)
Differential requirement for c-Jun NH2-terminal kinase in TNF-α- and Fas-mediated apoptosis in hepatocytes
RF Schwabe et al.
FASEB JOURNAL (2004)
Desensitization of the permeability transition pore by cyclosporin A prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-α
ME Soriano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation
T Uehara et al.
TRANSPLANTATION (2004)
A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme a carboxylase by soraphen A, a macrocyclic polyketide natural product
Y Shen et al.
MOLECULAR CELL (2004)
Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-α expression
WH Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
INK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
JJ Ventura et al.
GENES & DEVELOPMENT (2004)
Human CCAAT/enhancer-binding protein β gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence
C Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death
HM Shen et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS
T Sasazuki et al.
MOLECULAR IMMUNOLOGY (2004)
Curcumin inhibits NF-κB activation and reduces the severity of experimental steatohepatitis in mice
IA Leclercq et al.
JOURNAL OF HEPATOLOGY (2004)
Oxygen, reactive oxygen species and tissue damage
CM Bergamini et al.
CURRENT PHARMACEUTICAL DESIGN (2004)
Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species
CG Pham et al.
CELL (2004)
Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade
GF Zhou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
S Ishii et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease
DQ Gao et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2004)
A trip to the ER: coping with stress
DT Rutkowski et al.
TRENDS IN CELL BIOLOGY (2004)
Metabolic syndrome without obesity:: Hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice
JM Paterson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Defects in adaptive energy metabolism with CNS-Linked hyperactivity in PGC-1α null mice
JD Lin et al.
CELL (2004)
Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis
C Namikawa et al.
JOURNAL OF HEPATOLOGY (2004)
Identification of sequences responsible for intracellular targeting and membrane binding of rat CYP2E1 in yeast
EPA Neve et al.
BIOCHEMISTRY (2003)
Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses
SS Leonard et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals
HJ Harwood et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
O Gavrilova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1
JJ Song et al.
BIOCHEMICAL JOURNAL (2003)
NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
S Sakon et al.
EMBO JOURNAL (2003)
Acetyl-CoA carboxylase β gene is regulated by sterol regulatory element-binding protein-1 in liver
SY Oh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis
AE Feldstein et al.
GASTROENTEROLOGY (2003)
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
O Micheau et al.
CELL (2003)
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
AM Xu et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Gab1 is an integrator of cell death versus cell survival signals in oxidative stress
M Holgado-Madruga et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
T Yamauchi et al.
NATURE (2003)
JunD mediates survival signaling by the JNK signal transduction pathway
JA Lamb et al.
MOLECULAR CELL (2003)
Bile acid regulation of C/EBPβ, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes
L Qiao et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
YX Wang et al.
CELL (2003)
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
K Lei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Hepatic cytochrome p450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
N Chalasani et al.
HEPATOLOGY (2003)
The effects of dietary n-3 polyunsaturated fatty acids delivered in chylomicron remnants on the transcription of genes regulating synthesis and secretion of very-low-density lipoprotein by the liver: Modulation by cellular oxidative state
KM Botham et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2003)
Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells
H Imai et al.
FREE RADICAL BIOLOGY AND MEDICINE (2003)
Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB-C/EBP-β complex formation
R Kleemann et al.
BLOOD (2003)
Role of glutaredoxin in metabolic oxidative stress -: Glutaredoxin as a sensor of oxidative stress mediated by H2O2
JJ Song et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Phosphorylation and inactivation of myelbid cell leukemia 1 by JNK in response to oxidative stress
S Inoshita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
T Yamauchi et al.
NATURE MEDICINE (2002)
Leptin: a review of its peripheral actions and interactions
S Margetic et al.
INTERNATIONAL JOURNAL OF OBESITY (2002)
Animal models of steatohepatitis
A Koteish et al.
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2002)
Possible physiological roles of mitochondrial uncoupling proteins -: UCPn
P Jezek
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2002)
Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice
C Demeilliers et al.
GASTROENTEROLOGY (2002)
Reactive oxygen species production by the mitochondrial respiratory chain in isolated rat hepatocytes and liver mitochondria: studies using myxothiazol
TA Young et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)
Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression
IN Zelko et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Leptin is essential for the hepatic fibrogenic response to chronic liver injury
IA Leclercq et al.
JOURNAL OF HEPATOLOGY (2002)
Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: A manifestation of lipotoxicity?
S Chitturi et al.
HEPATOLOGY (2002)
Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner
YM Liu et al.
CIRCULATION RESEARCH (2002)
Nuclear activators and coactivators in mammalian mitochondrial biogenesis
RC Scarpulla
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2002)
Accumulation of 8-hydroxy-2′-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats
M Kakimoto et al.
DIABETES (2002)
Leptin in hepatic fibrosis:: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
NK Saxena et al.
HEPATOLOGY (2002)
NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun
HL Liu et al.
HEPATOLOGY (2002)
Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes
H Aoki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression
KJ Woodcroft et al.
HEPATOLOGY (2002)
Nonalcoholic steatosis and steatohepatitis v. mitochondrial dysfunction in steatohepatitis
D Pessayre et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Y Minokoshi et al.
NATURE (2002)
Immunohistochemical detection of myeloperoxidase and its oxidation products in Kupffer cells of human liver
KE Brown et al.
AMERICAN JOURNAL OF PATHOLOGY (2001)
Nonalcoholic steatosis and steatohepatitis -: III.: Peroxisomal β-oxidation, PPARα, and steatohepatitis
JK Reddy
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
J Nordberg et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
Alcohol-induced free radicals in mice:: Direct toxicants or signaling molecules?
M Yin et al.
HEPATOLOGY (2001)
Oxidized low-density lipoproteins bind to the scavenger receptor, CD36, of hepatic stellate cells and stimulate extracellular matrix synthesis
W Schneiderhan et al.
HEPATOLOGY (2001)
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
S Herzig et al.
NATURE (2001)
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
JC Yoon et al.
NATURE (2001)
Coupling endoplasmic reticulum stress to the cell death program - Mechanism of caspase activation
RV Rao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ
MS Yuan et al.
SCIENCE (2001)
Cytokine receptors and signaling in hepatic stellate cells
M Pinzani et al.
SEMINARS IN LIVER DISEASE (2001)
Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-α-induced liver injury
YG Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A
SI Yamagishi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk
K Mitrunen et al.
CARCINOGENESIS (2001)
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
T Yoneda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1)
EPA Neve et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
AJ Sanyal et al.
GASTROENTEROLOGY (2001)
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
L Abu-Elheiga et al.
SCIENCE (2001)
Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway
JF Louet et al.
BIOCHEMICAL JOURNAL (2001)
Role of novel markers of inflammation in patients with stable coronary heart disease
A Hoffmeister et al.
AMERICAN JOURNAL OF CARDIOLOGY (2001)
Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis
J Himms-Hagen et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2001)
Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes
R Garesse et al.
GENE (2001)
Peroxisome proliferator-activated receptor α activates transcription of the brown fat uncoupling protein-1 gene -: A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell
MJ Barberá et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
J Ye et al.
MOLECULAR CELL (2000)
Metabolism and functions of glutathione in brain
R Dringen
PROGRESS IN NEUROBIOLOGY (2000)
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
JJ Repa et al.
GENES & DEVELOPMENT (2000)
Signal transduction by the JNK group of MAP kinases
RJ Davis
CELL (2000)
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
H Kono et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Mitochondrial adaptations to obesity-related oxidant stress
SQ Yang et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)
Molecular basis for the transport of cytochrome P450 2E1 to the plasma membrane
EPA Neve et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
IA Leclercq et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
The PPARs: From orphan receptors to drug discovery
TM Willson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
F Urano et al.
SCIENCE (2000)
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
T Nakagawa et al.
NATURE (2000)
Peroxisomal Lipid Degradation via beta-and alpha-oxidation in mammals
GP Mannaerts et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2000)
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