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CHEMICO-BIOLOGICAL INTERACTIONS (2006)
Redox behavior of tumor-inhibiting ruthenium(III) complexes and effects of physiological reductants on their binding to GMP
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DALTON TRANSACTIONS (2006)
Interactions of antitumor metallodrugs with serum proteins: Advances in characterization using modern analytical methodology
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The endoplasmic reticulum: Folding, calcium homeostasis, signaling, and redox control
Agnes Goerlach et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: Detection of a sulfenato intermediate
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Gold(III) porphyrin 1a induced apoptosis by mitochondrial death pathways related to reactive oxygen species
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CANCER RESEARCH (2005)
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
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NATURE GENETICS (2005)
Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells
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BLOOD (2005)
A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness
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INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2005)
Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients
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VIRCHOWS ARCHIV (2005)
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
AB Witte et al.
FREE RADICAL BIOLOGY AND MEDICINE (2005)
The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells
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CANCER LETTERS (2005)
Interactions of sodium selenite, glutathione, arsenic species, and omega class human glutathione transferase
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CHEMICAL RESEARCH IN TOXICOLOGY (2005)
Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling
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FREE RADICAL BIOLOGY AND MEDICINE (2005)
The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosol
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TOXICOLOGICAL SCIENCES (2005)
Redox-active antineoplastic ruthenium complexes with indazole: Correlation of in vitro potency and reduction potential
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JOURNAL OF MEDICINAL CHEMISTRY (2005)
Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype
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TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)
A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19
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ARCHIVES OF TOXICOLOGY (2005)
Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells
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JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2005)
Antitumor-active cobalt-alkyne complexes derived from acetylsalicylic acid: Studies on the mode of drug action
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JOURNAL OF MEDICINAL CHEMISTRY (2005)
Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage
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BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)
Iron metabolism and toxicity
G Papanikolaou et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)
Recognition and processing of cisplatin- and oxaliplatin-DNA adducts
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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2005)
Two dimensional separation schemes for investigation of the interaction of an anticancer ruthenium( III) compound with plasma proteins
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JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY (2005)
Update of the preclinical situation of anticancer platinum complexes: Novel design strategies and innovative analytical approaches
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CURRENT MEDICINAL CHEMISTRY (2005)
Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes
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CHEMICAL COMMUNICATIONS (2005)
Balancing acts: Molecular control of mammalian iron metabolism
MW Hentze et al.
CELL (2004)
Vanadium - an element of atypical biological significance
B Mukherjee et al.
TOXICOLOGY LETTERS (2004)
Protection against zinc toxicity by metallothionein and zinc transporter 1
RD Palmiter
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Endogenous reductants support the catalytic function of recombinant rat Cyt19, an arsenic methyltransferase
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CHEMICAL RESEARCH IN TOXICOLOGY (2004)
Structure of the human transferrin receptor-transferrin complex
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CELL (2004)
Cobalt enhances DNA cleavage mediated by human topoisomerase IIα in vitro and in cultured cells
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BIOCHEMISTRY (2004)
Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: Implication for their use in targeting oxidation-reduction reactions in innate immunity
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FREE RADICAL BIOLOGY AND MEDICINE (2004)
The mechanism of action of platinum(IV) complexes in ovarian cancer cell lines
MD Hall et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2004)
Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA
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ONCOGENE (2004)
The potential of arsenic trioxide in the treatment of malignant disease: past, present, and future
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LEUKEMIA RESEARCH (2004)
Optimization of the auxiliary ligand shell of cobalt(III)(8-hydroxyquinoline) complexes as model hypoxia-selective radiation-activated prodrugs
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RADIATION RESEARCH (2004)
A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species
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TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)
Development of cobalt(3,4-diarylsalen) complexes as tumor therapeutics
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JOURNAL OF MEDICINAL CHEMISTRY (2004)
Tuning of redox potentials for the design of ruthenium anticancer drugs -: An electrochemical study of [trans-RuCl4L(DMSO)]- and [trans-RuCl42]- complexes, where L = imidazole, 1,2,4-triazole, indazole
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INORGANIC CHEMISTRY (2004)
A phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent
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CLINICAL CANCER RESEARCH (2004)
A comparative study of adduct formation between the anticancer ruthenium(III) compound HInd trans-[RuCl4(Ind)2] and serum proteins
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JOURNAL OF INORGANIC BIOCHEMISTRY (2004)
Co(II) and Cd(II) substitute for Zn(II) in the zinc finger derived from the DNA repair protein XPA, demonstrating a variety of potential mechanisms of toxicity
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CHEMICAL RESEARCH IN TOXICOLOGY (2004)
Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: Results of a randomized phase III trial
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JOURNAL OF CLINICAL ONCOLOGY (2004)
Structure, function, and mechanism of ribonucleotide reductases
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BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
Reactive oxygen species in vascular biology: implications in hypertension
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HISTOCHEMISTRY AND CELL BIOLOGY (2004)
Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions
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JOURNAL OF INORGANIC BIOCHEMISTRY (2004)
Labile iron pool: the main determinant of cellular response to oxidative stress
M Kruszewski
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
Synthesis, characterization and biological properties of a novel copper complex
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)
Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2+triazoIe)Ru(III) complexes
VB Arion et al.
INORGANIC CHEMISTRY (2003)
Platinum(II) catalysis and radical intervention in reductions of platinum(IV) antitumor drugs by ascorbic acid
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JOURNAL OF INORGANIC BIOCHEMISTRY (2003)
Analysis of glutathione: implication in redox and detoxification
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CLINICA CHIMICA ACTA (2003)
Antianglogenic properties of selected ruthenium(III) complexes that are nitric oxide scavengers
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BRITISH JOURNAL OF CANCER (2003)
Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells
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CANCER CELL (2003)
Gold compound auranofin inhibits IκB kinase (IKK) by modifying Cys-179 of IKKβ subunit
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EXPERIMENTAL AND MOLECULAR MEDICINE (2003)
Selective induction of liver parenchymal cell heme oxygenase-1 in selenium-deficient rats
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BIOLOGICAL CHEMISTRY (2003)
Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice
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MOLECULAR AND CELLULAR BIOLOGY (2003)
Redox-active cobalt complexes as promising antitumor agents
SP Osinsky et al.
RUSSIAN CHEMICAL BULLETIN (2003)
Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway
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PHARMACOLOGICAL REVIEWS (2002)
Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity
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EXPERT OPINION ON INVESTIGATIONAL DRUGS (2002)
The labile iron pool: Characterization, measurement, and participation in cellular processes
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FREE RADICAL BIOLOGY AND MEDICINE (2002)
The role of NF-κB in the regulation of cell stress responses
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INTERNATIONAL IMMUNOPHARMACOLOGY (2002)
Platinum(IV) antitumour compounds: their bioinorganic chemistry
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COORDINATION CHEMISTRY REVIEWS (2002)
A minor groove binding copper-phenanthroline conjugate produces direct strand breaks via β-elimination of 2-deoxyribonolactone
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Modulation of the thioredoxin system during inflammatory responses and its effect on heme oxygenase-1 expression
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ANTIOXIDANTS & REDOX SIGNALING (2002)
Rhodium and its compounds as potential agents in cancer treatment
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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2002)
JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation, glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin
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BIOCHEMICAL PHARMACOLOGY (2002)
Vanadium in cancer treatment
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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2002)
Synthesis and characterization of cobalt and nickel chelates of 5-dimethylaminomethyl-2-thiouracil and their evaluation as antimicrobial and anticancer agents
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JOURNAL OF INORGANIC BIOCHEMISTRY (2002)
In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer
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BRITISH JOURNAL OF CANCER (2002)
Transferrin/transferrin receptor-mediated drug delivery
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MEDICINAL RESEARCH REVIEWS (2002)
The role of the transferrin-transferrin-receptor system in drug delivery and targeting
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TRENDS IN PHARMACOLOGICAL SCIENCES (2002)
DNA-fiber EPR study of the orientation of Cu(II) complexes of 1,10-phenanthroline and its derivatives bound to DNA: mono(phenanthroline)-copper(II) and its ternary complexes with amino acids
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Gold(III) complexes with bipyridyl ligands: Solution chemistry, cytotoxicity, and DNA binding properties
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JOURNAL OF MEDICINAL CHEMISTRY (2002)
Kinetics and mechanism for reduction of halo- and haloam(m)ine platinum(IV) complexes by L-ascorbate
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INORGANICA CHIMICA ACTA (2002)
Influence of chemical stability on the activity of the antimetastasis ruthenium compound NAMI-A
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EUROPEAN JOURNAL OF CANCER (2002)
Generation of reactive oxygen species by the mitochondrial electron transport chain
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JOURNAL OF NEUROCHEMISTRY (2002)
Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex
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FREE RADICAL BIOLOGY AND MEDICINE (2001)
United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia
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JOURNAL OF CLINICAL ONCOLOGY (2001)
Human thioredoxin reductase is efficiently inhibited by (2,2′:6′,2-terpyridine)platinum(II) complexes.: Possible implications for a novel antitumor strategy
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JOURNAL OF MEDICINAL CHEMISTRY (2001)
Human monomethylarsonic acid (MMAV) reductase is a member of the glutathione-S-transferase superfamily
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CHEMICAL RESEARCH IN TOXICOLOGY (2001)
Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells
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BLOOD (2001)
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2001)
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FREE RADICAL BIOLOGY AND MEDICINE (2001)
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CHEMICAL RESEARCH IN TOXICOLOGY (2001)
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CURRENT MEDICINAL CHEMISTRY (2000)
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