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CHEMICO-BIOLOGICAL INTERACTIONS (2006)
Redox behavior of tumor-inhibiting ruthenium(III) complexes and effects of physiological reductants on their binding to GMP
P Schluga et al.
DALTON TRANSACTIONS (2006)
Interactions of antitumor metallodrugs with serum proteins: Advances in characterization using modern analytical methodology
Andrei R. Timerbaev et al.
CHEMICAL REVIEWS (2006)
The endoplasmic reticulum: Folding, calcium homeostasis, signaling, and redox control
Agnes Goerlach et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: Detection of a sulfenato intermediate
FY Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Gold(III) porphyrin 1a induced apoptosis by mitochondrial death pathways related to reactive oxygen species
Y Wang et al.
CANCER RESEARCH (2005)
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
RS Ohgami et al.
NATURE GENETICS (2005)
Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells
H Glickstein et al.
BLOOD (2005)
A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness
BJ Moeller et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2005)
Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients
P Surowiak et al.
VIRCHOWS ARCHIV (2005)
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
AB Witte et al.
FREE RADICAL BIOLOGY AND MEDICINE (2005)
The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells
S Kapitza et al.
CANCER LETTERS (2005)
Interactions of sodium selenite, glutathione, arsenic species, and omega class human glutathione transferase
RA Zakharyan et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2005)
Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling
SG Rhee et al.
FREE RADICAL BIOLOGY AND MEDICINE (2005)
The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosol
Z Gregus et al.
TOXICOLOGICAL SCIENCES (2005)
Redox-active antineoplastic ruthenium complexes with indazole: Correlation of in vitro potency and reduction potential
MA Jakupec et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype
JX Li et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)
A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19
T Hayakawa et al.
ARCHIVES OF TOXICOLOGY (2005)
Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells
S Kapitza et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2005)
Antitumor-active cobalt-alkyne complexes derived from acetylsalicylic acid: Studies on the mode of drug action
I Ott et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage
H Weissbach et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)
Iron metabolism and toxicity
G Papanikolaou et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)
Recognition and processing of cisplatin- and oxaliplatin-DNA adducts
SG Chaney et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2005)
Two dimensional separation schemes for investigation of the interaction of an anticancer ruthenium( III) compound with plasma proteins
M Sulyok et al.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY (2005)
Update of the preclinical situation of anticancer platinum complexes: Novel design strategies and innovative analytical approaches
M Galanski et al.
CURRENT MEDICINAL CHEMISTRY (2005)
Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes
YK Yan et al.
CHEMICAL COMMUNICATIONS (2005)
Balancing acts: Molecular control of mammalian iron metabolism
MW Hentze et al.
CELL (2004)
Vanadium - an element of atypical biological significance
B Mukherjee et al.
TOXICOLOGY LETTERS (2004)
Protection against zinc toxicity by metallothionein and zinc transporter 1
RD Palmiter
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Endogenous reductants support the catalytic function of recombinant rat Cyt19, an arsenic methyltransferase
SB Waters et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2004)
Structure of the human transferrin receptor-transferrin complex
Y Cheng et al.
CELL (2004)
Cobalt enhances DNA cleavage mediated by human topoisomerase IIα in vitro and in cultured cells
EL Baldwin et al.
BIOCHEMISTRY (2004)
Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: Implication for their use in targeting oxidation-reduction reactions in innate immunity
HM Tse et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
The mechanism of action of platinum(IV) complexes in ovarian cancer cell lines
MD Hall et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2004)
Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA
I Gourdier et al.
ONCOGENE (2004)
The potential of arsenic trioxide in the treatment of malignant disease: past, present, and future
AM Evens et al.
LEUKEMIA RESEARCH (2004)
Optimization of the auxiliary ligand shell of cobalt(III)(8-hydroxyquinoline) complexes as model hypoxia-selective radiation-activated prodrugs
GO Ahn et al.
RADIATION RESEARCH (2004)
A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species
HV Aposhian et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)
Development of cobalt(3,4-diarylsalen) complexes as tumor therapeutics
R Gust et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Tuning of redox potentials for the design of ruthenium anticancer drugs -: An electrochemical study of [trans-RuCl4L(DMSO)]- and [trans-RuCl42]- complexes, where L = imidazole, 1,2,4-triazole, indazole
E Reisner et al.
INORGANIC CHEMISTRY (2004)
A phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent
JM Rademaker-Lakhai et al.
CLINICAL CANCER RESEARCH (2004)
A comparative study of adduct formation between the anticancer ruthenium(III) compound HInd trans-[RuCl4(Ind)2] and serum proteins
F Piccioli et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2004)
Co(II) and Cd(II) substitute for Zn(II) in the zinc finger derived from the DNA repair protein XPA, demonstrating a variety of potential mechanisms of toxicity
E Kopera et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2004)
Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: Results of a randomized phase III trial
CA Meyers et al.
JOURNAL OF CLINICAL ONCOLOGY (2004)
Structure, function, and mechanism of ribonucleotide reductases
M Kolberg et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
Reactive oxygen species in vascular biology: implications in hypertension
RM Touyz et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2004)
Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions
MP Rigobello et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2004)
Labile iron pool: the main determinant of cellular response to oxidative stress
M Kruszewski
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
Synthesis, characterization and biological properties of a novel copper complex
S Majumder et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)
Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2+triazoIe)Ru(III) complexes
VB Arion et al.
INORGANIC CHEMISTRY (2003)
Platinum(II) catalysis and radical intervention in reductions of platinum(IV) antitumor drugs by ascorbic acid
EL Weaver et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2003)
Analysis of glutathione: implication in redox and detoxification
A Pastore et al.
CLINICA CHIMICA ACTA (2003)
Antianglogenic properties of selected ruthenium(III) complexes that are nitric oxide scavengers
L Morbidelli et al.
BRITISH JOURNAL OF CANCER (2003)
Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine
K Anestål et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells
AS Don et al.
CANCER CELL (2003)
Gold compound auranofin inhibits IκB kinase (IKK) by modifying Cys-179 of IKKβ subunit
KI Jeon et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2003)
Selective induction of liver parenchymal cell heme oxygenase-1 in selenium-deficient rats
V Mostert et al.
BIOLOGICAL CHEMISTRY (2003)
Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling
A Mandic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice
L Nonn et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Redox-active cobalt complexes as promising antitumor agents
SP Osinsky et al.
RUSSIAN CHEMICAL BULLETIN (2003)
Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway
ZM Qian et al.
PHARMACOLOGICAL REVIEWS (2002)
Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity
OJ D'Cruz et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2002)
The labile iron pool: Characterization, measurement, and participation in cellular processes
O Kakhlon et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
The role of NF-κB in the regulation of cell stress responses
TL Wang et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2002)
Platinum(IV) antitumour compounds: their bioinorganic chemistry
MD Hall et al.
COORDINATION CHEMISTRY REVIEWS (2002)
A minor groove binding copper-phenanthroline conjugate produces direct strand breaks via β-elimination of 2-deoxyribonolactone
BC Bales et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Modulation of the thioredoxin system during inflammatory responses and its effect on heme oxygenase-1 expression
K Ejima et al.
ANTIOXIDANTS & REDOX SIGNALING (2002)
Rhodium and its compounds as potential agents in cancer treatment
N Katsaros et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2002)
JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation, glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin
E Fokkema et al.
BIOCHEMICAL PHARMACOLOGY (2002)
Vanadium in cancer treatment
AM Evangelou
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2002)
Synthesis and characterization of cobalt and nickel chelates of 5-dimethylaminomethyl-2-thiouracil and their evaluation as antimicrobial and anticancer agents
P Kamalakannan et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2002)
In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer
RE Aird et al.
BRITISH JOURNAL OF CANCER (2002)
Transferrin/transferrin receptor-mediated drug delivery
HY Li et al.
MEDICINAL RESEARCH REVIEWS (2002)
The role of the transferrin-transferrin-receptor system in drug delivery and targeting
HY Li et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2002)
DNA-fiber EPR study of the orientation of Cu(II) complexes of 1,10-phenanthroline and its derivatives bound to DNA: mono(phenanthroline)-copper(II) and its ternary complexes with amino acids
M Chikira et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2002)
Gold(III) complexes with bipyridyl ligands: Solution chemistry, cytotoxicity, and DNA binding properties
G Marcon et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Kinetics and mechanism for reduction of halo- and haloam(m)ine platinum(IV) complexes by L-ascorbate
K Lemma et al.
INORGANICA CHIMICA ACTA (2002)
Influence of chemical stability on the activity of the antimetastasis ruthenium compound NAMI-A
G Sava et al.
EUROPEAN JOURNAL OF CANCER (2002)
Generation of reactive oxygen species by the mitochondrial electron transport chain
YB Liu et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex
ESJ Arnér et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia
SL Soignet et al.
JOURNAL OF CLINICAL ONCOLOGY (2001)
Human thioredoxin reductase is efficiently inhibited by (2,2′:6′,2-terpyridine)platinum(II) complexes.: Possible implications for a novel antitumor strategy
K Becker et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Human monomethylarsonic acid (MMAV) reductase is a member of the glutathione-S-transferase superfamily
RA Zakharyan et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2001)
Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells
JM Grad et al.
BLOOD (2001)
Prodrug strategies in cancer therapy
WA Denny
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2001)
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
FQ Schafer et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
DNA cleavage by photogenerated Rh2(O2CCH3)4(H2O)2+
PKL Fu et al.
INORGANIC CHEMISTRY (2001)
Redox and ligand exchange reactions of potential gold(I) and gold(III)-cyanide metabolites under biomimetic conditions
AJ Canumalla et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2001)
Multicenter phase Ib/II trial of the radiation enhancer motexafin gadolinium in patients with brain metastases
P Carde et al.
JOURNAL OF CLINICAL ONCOLOGY (2001)
Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes
S Lin et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2001)
Biosynthesis of cobalamin (vitamin B12):: a bacterial conundrum
E Raux et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2000)
Antitumour metallocenes: Structure-activity studies and interactions with biomolecules
MM Harding et al.
CURRENT MEDICINAL CHEMISTRY (2000)
Vanadium-induced κB-dependent transcription depends upon peroxide-induced activation of the p38 mitogen-activated protein kinase
I Jaspers et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2000)
Kinetics and mechanism for reduction of anticancer-active tetrachloroam(m)ine platinum(IV) compounds by glutathione
K Lemma et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2000)
Conversion constants for redox potentials measured versus different reference electrodes in acetonitrile solutions at 25°C
VV Pavlishchuk et al.
INORGANICA CHIMICA ACTA (2000)
Synthesis, structures and hypoxia-selective cytotoxicity of cobalt(III) complexes containing tridentate amine and nitrogen mustard ligands
DC Ware et al.
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS (2000)
Kinetics and mechanism for reduction of oral anticancer platinum(IV) dicarboxylate compounds by L-ascorbate ions
K Lemma et al.
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS (2000)
Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes
JS Petrick et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2000)