Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 15, Issue 5, Pages 528-535Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2005.04.015
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Funding
- NIAMS NIH HHS [Z01 AR041126-06] Funding Source: Medline
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During skeletal myogenesis, chromatin-modifying enzymes are engaged at discrete genomic regions by transcription factors that recognize sequence-specific DNA motifs located at muscle gene regulatory regions. The composition of the chromatin-bound protein complexes and their temporally and spatially regulated recruitment influence gene expression. Recent findings are consistent with the concept that chromatin modifiers play an important role in regulating skeletal muscle gene expression and cellular differentiation.
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